Otto fischer



UNITED STATES PATENT OFFICE.

OTTO FISCHER, OF MUN IOH, ASSIGN OR TO FARBWERKE, VORMALS MEISTER,LUOIUS 8t BRUNING, OF HOOHST-ON-THE-MAIN, GERMANY.

PREPARATION OF OXYHYDRO-METHYL CHINOL'INE.

SPECIFICATION forming part of Letters Patent No. 276,796, dated May 1,1883.

Application filed February 10, 1883. (No specimens.) Patented in GermanyMarch 21, 1882, No. 21,150; in England June 28, 1882. No. 3,044, and inRussia. September 7, 1882, No. 6,456.

To all whom it may concern:

Be it known that I, OTTO FISCHER, a citizen ot' the Empire of Germany,residing at Munich, Germany, have invented certain new and usefulImprovements in the Production of ,Oxyhydro-MethylOhinoline, of whichthe folfrom coal-tar contain, besidesother bases, chinoline and itshomolognes, which may be separated by fractionate distillation,treatment with weak oxidizing agents, or by other suitable methods. Itis, however, chinoline which is of interest to me, as from this base Ihave obtained by aseries of operations new compounds which I find to bevaluable medical agents.

I have described in my patentfor.oxyhydroethyl chinoline, No. 273,498, amethod of 0btaining oxychinoline, which begins with pure chiuolinesulpho-acid and its conversion into oxychinoline and oxysul'iho-chinoline and terminating in oxyhydro ethyl chinoline. In thepresent application it is my object to obtain oxyhydro-methyl chinolinein which the early steps followed in the process are the same as thoseof said patent as far as the production of oxyhydro-chinoline isconcerned.v

In the manufacture of the chinolinemethyl salt I proceed as follows: Onemolecule of alpha oxyhydro-chinoline is heated upon the water bath withone molecule of methyl iodide until the reaction, which is violent atfirst, has

come to a standstill. From the crystalline mass obtained on cooling thehydro-iodide of oxyhydro methyl chinoline is extracted by means ofwater, and the new base itself is precipitated from the aqueous solutionof the salt by means of caustic soda. It is afterward purified bycrystallization from ether.

Instead of methyl iodide methyl chloride or bromide may be used.

For, use the base is transformed into the respective salt by means ofhydrochloric, sulphuric, or other acids.

Havingthusdescribed my invention,what I claim as new, and desire tosecure by Letters.

2. Oxyhydro-methyl chinoline prepared by the process herein described.

In testimony whereofl have aflixed my signature in presence of twowitnesses.

OTTO FISCHER. Witnesses:

' J 0s. W. HARPER,

EMIL HENZEL.

